T4TE Project 1

Motor TMS-Evoked Potentials (M1-TEPs)

Project overview

The T4TE Project 1 aims at investigating the reliability, validity and possible biomarkers development of the TMS-Evoked Potentials (TEPs) elicited by stimulating the primary motor cortex (M1) through multiple studies

Study 1.1 Reliability of M1-TEPs

Progress: Joining labs have been contacted for the first online meeting on January 18th

Study overview

The main aim of Study 1.1 is testing the reliability of TEPs elicited by stimulating M1 to variations in procedures across labs. Specifically, Study 1.1 is designed to disentangle the effects of flexibility in data acquisition and in data processing on TEPs. Moreover, it will investigate the direct effect of flexibility on: a) the comparison of TEPs in trials of high and low cortical excitability, as indexed by motor-evoked potentials (MEPs), and b) the effect of prestimulus oscillations on TEPs.


Study 1.1 is currently enrolling participating labs/researchers.

Join the project by the 31st of December 2022 by writing to contact.T4TE@gmail.com


Participation in T4TE - Study 1.1 is open to single researchers, research groups and labs, who can join either collecting or analysing data or both.

Requirements for data acquisition

  • Meet the minimum criteria in equipment settings for TMS-EEG coregistration:

TMS: Monophasic or biphasic TMS with standard figure-of-eight coil

EEG: Sampling rate > 4000 Hz, High-pass filter: DC recording or < 0.1 Hz, Low-pass filter > 1000 Hz; Channels > 60 passive or active placed according to the 10-10 International EEG system

EMG: At least 3 bipolar channels, Sampling rate > 1000 Hz

  • Commitment to collect 25 young healthy participants

  • Show evidence of high-quality data collection in the “quality check” phase of the study (before data collection)

  • Provide a detailed report on the acquisition procedures

  • Share the raw data and meta-files in open repositories

Requirements for data analyses

  • Commitment to analyse three datasets (of which at least two recorded from other labs)

  • Provide a detailed report of the analyses pipeline

  • Show evidence of quality checks before performing the analyses

  • Share codes and preprocessed data in open repositories

If you do not meet the requirements but would like to contribute, please let us know.


  • 3 authors for participating in data collection only

  • 1 author for participating in data analysis only

  • 4 authors for participating in both data collection and analysis

Tentative timeline

  • September - December 2022: Open call for participating labs will be open

  • January 2023: Open discussion of the experimental design

  • February – July 2023: Ethics approval for all participating labs & registered report preparation/submission.

  • August – September 2023: Quality checks

  • September – March 2024: Data collection

  • March-September 2024: Data analyses completed

  • March 2025: Submission of stage 2 registered report

Join the Initiative!


Participating Labs