T4TE Project 1

Motor TMS-Evoked Potentials (M1-TEPs)

Project overview

The T4TE Project 1 aims at investigating the reliability, validity and possible biomarkers development of the TMS-Evoked Potentials (TEPs) elicited by stimulating the primary motor cortex (M1) through multiple studies

Study 1.1 Reliability of M1-TEPs

Progress: Joining labs had the second online meeting on March 3rd. Stay tuned! 

Study overview

The main aim of Study 1.1 is testing the reliability of TEPs elicited by stimulating M1 to variations in procedures across labs. Specifically, Study 1.1 is designed to disentangle the effects of flexibility in data acquisition and in data processing on TEPs. Moreover, it will investigate the direct effect of flexibility on: a) the comparison of TEPs in trials of high and low cortical excitability, as indexed by motor-evoked potentials (MEPs), and b) the effect of prestimulus oscillations on TEPs.


Study 1.1 is currently working on the preparation of Ethics documentation and the Registered Report Stage 1.


Participation in T4TE - Study 1.1 is open to single researchers, research groups and labs, who can join either collecting or analysing data or both. 

Requirements for data acquisition

TMS: Monophasic or biphasic TMS with standard figure-of-eight coil 

EEG:  Sampling rate > 4000 Hz, High-pass filter: DC recording or < 0.1 Hz, Low-pass filter > 1000 Hz; Channels > 60 passive or active placed according to the 10-10 International EEG system

EMG: At least 3 bipolar channels, Sampling rate > 1000 Hz

Requirements for data analyses

If you do not meet the requirements but would like to contribute, please let us know.


Tentative timeline 

Join the Initiative! 


Participating Labs